Increase In New MRSA Strains In Non-Hospital Environment

Microbiologists from the Dental School in Trinity College Dublin, in collaboration with the National MRSA Reference Laboratory and Alere Technologies in Germany, have identified significant increases in the prevalence, genetic diversity and antimicrobial resistance of PVL-positive MRSA circulating in Ireland in the 10 years between 2002-2011.

These findings have just been published in the March 2014 issue of a leading, peer reviewed international journal, The Journal of Clinical Microbiology.

PVL-positive MRSA strains are more likely to be found among individuals in the community rather than in a hospital setting which is where MRSA is usually associated. The Panton-Valentine leukocidin (PVL) toxin can enhance the ability of S. aureus (the bacteria Staphylococcus aureus) to cause disease through the destruction of white blood cells and damage to skin and soft tissues.

Among MRSA samples submitted to the Irish National MRSA Reference Laboratory between 2002 and 2011, the authors identified a 44-fold increase in the prevalence of PVL-positive MRSA and a six-fold increase in the number of PVL-positive MRSA samples resistant to multiple antibiotics.

Unlike MRSA strains that traditionally cause invasive infections among older and vulnerable patients in hospitals, many of whom may have underlying infections, these PVL-positive MRSA strains were predominantly identified among younger individuals in the community and were mostly associated with skin and soft tissue infections, although serious and life threatening bloodstream infections and necrotising pneumonia were also identified.

Commenting on the significance of the findings, Professor David Coleman, Professor and Chair of Oral and Applied Microbiology, School of Dental Science, Trinity said: "The increased burden of PVL-positive and multi-antibiotic resistant PVL-positive MRSA in Ireland over the last decade is a worrying development and enhanced surveillance in both hospitals and communities is vital to ensure that these strains do not spread and become more established.

"Rapid and informative high-throughput molecular typing using DNA microarrays and ultimately whole-genome sequencing will be essential in preventing the spread of these strains."

(CD/JP)